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Ozempic and Wegovy are brands of semaglutide. It is a long-acting GLP-1 agonist, which can be administered subcutaneously once a week.
It has been shown to be effective for weight loss in trials involving patients with and without type 2 diabetes. In fact, Ozempic was developed to treat type 2 diabetes because it helps reduce blood sugar levels.
But it ended up having a side benefit in terms of weight loss, which then carried over when people without type 2 diabetes began ordering Ozempic to help them lose weight.
Keep in mind that only the injectable form, Wegovy, is approved for the treatment of obesity (not the oral version).
Semglutide has also been shown to reduce cardiovascular (CV) risk factors in patients with established cardiovascular conditions in some cardiovascular outcomes trials.
How does Ozempic work for weight loss?
Once considered overweight or obese, treatment is as follows: Ozempic injections at the maximum dose (2.4 mg per week) achieve maximum weight loss.
But patients should not start on the maximum dose right away, because some cannot tolerate the dose and might have side effects, such as nausea or vomiting. Therefore, a gradual increase in dose is recommended.
The way semaglutide (Ozempic and Wegovy) works for weight loss is quite interesting. GLP-1 is a major incretin hormone in humans. That is, it increases insulin cross-section, inhibits glucagon release and suppresses hepatic gluconeogenesis.
Semaglutide also causes a delay in gastric emptying, a reduction in appetite and energy intake, which is why it has beneficial effects on weight loss. It reduces the rate at which your stomach empties food after a meal (gastric emptying). The longer the gastric emptying, the longer the food stays in your stomach, making you feel full longer.
This results in a reduction in hunger and appetite. Overall, patients on Ozempic or Wegovy end up eating less food and therefore losing weight.
Ozempic not only affects gastric emptying, but also GLP-1 receptors present in the hypothalamus, which are responsible for regulating food intake in the nervous system. This reduces the feeling of hunger and appetite in obese people.
Additionally, GLP-1 also affects receptors responsible for satiety in the brain. It stimulates these specific neurons, thereby increasing satiety in patients who received Ozempic. Now that you know what Ozempic is used for, let''s take a closer look at the dosage and other taking instructions.
Where can I inject Ozempic?
One study showed that taking Ozempic on an empty stomach has the most optimal effect on achieving therapeutic concentration. It is beneficial to fast for another half hour after taking the dose.
Additionally, Ozempic should be administered under the skin, in the subcutaneous or fatty layer, on the lower abdomen (near the waist), on the front of the thighs, or on the upper arm. Do not inject Ozempic into a muscle or vein.
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